Breast imaging
Case TypeClinical Cases
Authors
Vicente Belloch-Ripollés, Guillermina Montoliu-Fornás
Patient65 years, male
A 65-year-old man was referred to the breast unit for assessment of a lump in the left breast after one month of evolution. On physical examination, a painful cord-like induration was observed in the upper external quadrant of the left breast. Former smoker. No other relevant medical or surgical history.
Mammography showed breasts with fat content, highlighting in the left breast a thick and tortuous structure with a vascular appearance (Fig. 1).
On ultrasound, it was a hypoechoic, tubular structure (Fig. 2a), impossible to compress with the linear probe with an almost absent signal on colour Doppler (Fig. 2b), localized in the subcutaneous fat.
These findings correspond to a thrombosed superficial venous vessel or Mondor's disease.
Background
Mondor’s disease (MD) is a rare condition characterized by thrombophlebitis of the superficial veins of the anterior thoracoabdominal wall [1].
The real incidence of MD is unknown [2], probably due to its self-limited course. Previous studies estimate an incidence ratio between 0.07-0.96% in patients who attend breast consultations [1]. MD is much more common in women, with a female to male ratio between 9-14:1 [1], without racial or ethnic predilection [2]. The thoracoepigastric vein is the most frequently implicated [1], usually unilaterally, although some cases of bilateral affectation have been reported [1].
Similar abnormalities are described in other locations and are considered as variants of MD [3], such as penile MD [4], or axillary web syndrome [5]. In men, penile MD is an entity well-known and described, however, the involvement of the breast in a male is very rare, and there are few cases described [6].
MD is usually idiopathic (primary MD) [3], but is important to bear in mind that there may be an underlying cause [3], such as a hypercoagulative state, vasculitis, or neoplasms (secondary MD), which should be reasonably ruled out.
Clinical Perspective
MD manifests as a palpable, painful cord-like induration on the body surface, which may associate subtle inflammatory signs [3]. Diagnosis is mainly based on the clinical history and physical examination. Is important to assess the presence of risk factors that suggest secondary MD. Doppler ultrasound is the technique of choice to confirm the diagnosis [1].
Imaging Perspective
The favourite modality of imaging is ultrasound with a linear transducer [1]. It depicts a subcutaneous non-compressive tubular structure, with echogenic content and absence of flow signal on Doppler studies. It corresponds to a superficial venous thrombosis, which may or not associate subtle inflammatory changes in the surrounding subcutaneous fat tissue.
Mammography is usually performed when alternative diagnostic possibilities are considered. It reveals a superficial radiodense linear structure. Sometimes, due to the projection, it can acquire a nodular morphology, it is important to rule out primary breast tumours with ultrasound in these cases.
Outcome
MD is usually a self-limited disease that resolves within 4 to 8 weeks without the need for treatment or follow-up [3].
Take-Home Message/Teaching Points
MD is self-limited thrombophlebitis of the superficial veins of the anterior thoracoabdominal wall, much more frequent in women but, since it can also occur in men, should be considered in the differential diagnosis of male’s breast and chest lesions.
[1] Salemis NS, Vasilara G, Lagoudianakis E. Mondor’s disease of the breast as a complication of ultrasound-guided core needle biopsy: management and review of the literature. Breast Dis. 2015;35(1):73-6. (PMID: 24989360)
[2] Salemis NS, Merkouris S, Kimpouri K. Mondor’s disease of the breast. A retrospective review. Breast Dis. 1 de enero de 2012;33(3):103-7. (PMID: 22377612)
[3] Amano M, Shimizu T. Mondor’s Disease: A Review of the Literature. Intern Med Tokyo Jpn. 15 de septiembre de 2018;57(18):2607-12. (PMID: 29780120)
[4] Helm JD, Hodge IG. Thrombophlebitis of a dorsal vein of the penis; report of a case treated by phenylbutazone (butazolidin). J Urol. febrero de 1958;79(2):306-7. (PMID: 13514882)
[5] Moskovitz AH, Anderson BO, Yeung RS, Byrd DR, Lawton TJ, Moe RE. Axillary web syndrome after axillary dissection. Am J Surg. mayo de 2001;181(5):434-9. (PMID: 11448437)
[6] Isik A, Karavas E, Peker K, Soyturk M, Yilmaz I. Male Mondor’s Disease is a Rare Entity. Breast J. 2016;22(6):700-1. (PMID: 27550206)
URL: | https://eurorad.org/case/17392 |
DOI: | 10.35100/eurorad/case.17392 |
ISSN: | 1563-4086 |
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.