EURORAD ESR

Case 14863

The value of conventional and diffusion magnetic resonance imaging in a rare mitochondrial disorder: Leigh syndrome - a case report

Author(s)
Anastasia Zikou(1), Christina Naka(1), Meropi Tzoufi(2), Vaseilios Xydis(1), Maria I. Argyropoulou(1).

1.Department of Clinical Radiology, Medical School of Ioannina, Greece.
2. Department of Child Health, Medical School of Ioannina, Greece.
Email: anzikou@cc.uoi.gr
 
Patient
female, 9 month(s)
 
 
  • Figure 1
    T2‑weighted axial images
     

    T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;

    T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;

    T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;
     
     
  • Figure 2
    T1‑weighted axial images
     

    T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;

    T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;

    T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;
     
     
  • Figure 3
    DWI
     

    DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;
     
     
  • Figure 4
    T2‑weighted axial images
     

    T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;

    T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;

    T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Congenital;
     
     
  • Figure 5
    DWI
     

    DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;

    DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR-Diffusion/Perfusion; Procedure: Diagnostic procedure; Special Focus: Congenital;
     
     
T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).
 
T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).
 
T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).
 
T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).
 
T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).
 
T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).
 
DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).
 
T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).
 
T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).
 
DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).
 
 
 
Home Search Sections Teaching Cases History FAQ Case Archives Contact Login Disclaimer Imprint Switch to MOBILE version
View desktop version