The value of conventional and diffusion magnetic resonance imaging in a rare mitochondrial disorder: Leigh syndrome - a case report

Author(s)

Anastasia Zikou(1), Christina Naka(1), Meropi Tzoufi(2), Vaseilios Xydis(1), Maria I. Argyropoulou(1).

1.Department of Clinical Radiology, Medical School of Ioannina, Greece. 2. Department of Child Health, Medical School of Ioannina, Greece. Email: anzikou@cc.uoi.gr

T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

Area of Interest:Neuroradiology brain; Imaging Technique:MR-Diffusion/Perfusion; Procedure:Diagnostic procedure; Special Focus:Congenital;

T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

T2‑weighted axial images show bilateral, symmetrical hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

T1‑weighted axial images show bilateral, symmetrical hypointensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b,c)(arrows).

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show hyperintense signal on diffusion weighted image acquisition (a,b,c), or low signal on apparent diffusion coefficient maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

T2‑weighted axial images show bilateral, symmetrical mild hyperintensities in the substantia nigra (a) (curved arrow) the pallidus and the putamen (b, c) (arrows).

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).

DWI show mild hypointense signal on diffusion weighted image acquisition (a,b,c), or slight hyperintence signal on ADC maps (d,e,f) in the substantia nigra (curved arrow) the pallidus and the putamen (arrows).