Neuroradiology
Case TypeClinical Cases
Authors
Eliza Stavride, Katerina Manavi, Antonios Theodorakopoulos, Marianna Theodorou, Ioannis Tsitouridis
Patient51 years, male
A 51-year-old man presented complaining of neck and right arm pain. Neurological examination revealed paresis of the right upper extremity with power of 2/5. His workup next included magnetic resonance imaging (MRI), computed tomography scan (CT) and finally digital subtraction angiography (DSA).
Computed tomography and CTA revealed an enlarged epidural venous plexus destroying the right lamina and part of the body of C3 and C4, nearly occluding the foramina and compressing the right nerve roots. The dilated vessels were seen as hypointense mass on T1 and T2-weighted images, consistent with flow voids. Cord oedema and dilated perimedullary vessels were not observed. Gadolinium-enhanced T1- weighted images did not reveal enhancement within the cord. Digital subtraction angiography (DSA) showed the two main feeding arteries and the draining veins of the plexus.
Spinal arteriovenous lesions are predominantly classified in AVMs and AVFs. AVFs are further divided into intradural and extradural lesions, which constitute a direct connection between an extradural artery and vein and formation of a high-flow fistula [1]. Extradural AVFs develop in the ventral epidural space and are closely associated with the adjacent osseous structures. They are fed by multiple epidural branches and drain into the ventral epidural venous pouch [2, 3]. The increase in spinal venous pressure may lead to decreased drainage of normal spinal veins and secondary venous congestion, but less frequently than in dural AVFs, because the shunting vessels are related to structures developed from the notochord. If stenosis or thrombosis of the venous outflow occurs, the epidural venous system is engorged and this results in compression of the spinal cord or the spinal roots, and deteriorating myelopathy, due to the secondary increase in the pressure of perimedullary venous plexus.
Non-contrast CT is sensitive for the detection of subarachnoid haemorrhage and remodelling of the cortical bone in long-standing vascular enlargement. The pathological arteries and veins are opacified after intravenous infusion of contrast. On MR imaging, the engorgement of perimedullary vessels, cord oedema and enhancement are important diagnostic features of AVF [2, 4]. The dilated vessels can be seen as flow-voids on T2-weighted images, while the cord oedema is depicted as ill-defined, flame-shaped central hyperintensity often surrounded by hypointense rim, corresponding to deoxygenated blood. The cord oedema may be missing in the early stage. On T1-weighted images the cord appears slightly hypointense and enlarged. The administration of gadolinium reveals diffuse enhancement within the cord, especially in delayed images, as sign of chronic venous congestion and breakdown of the blood-spinal cord barrier. Haemorrhage may be observed if venous hypertension persists untreated. T2*-weighted imaging demonstrates low signal “blooming”, depending on the amount of haemorrhage.
Spinal angiography is necessary to find the exact level of the fistula and to visualise the feeding artery and the draining veins [1, 5, 6]. An extensive network of perimedullary veins may also be visualised.
Extradural AVFs can be treated with both endovascular and microsurgical approaches. The fistula is identified and disconnected using a small clip or electrocautery-assisted ligation. Following the occlusion of the shunt, progression of the disease can be stopped and improvement of symptoms is typically observed [5, 6].
Written informed patient consent for publication has been obtained.
[1] Spetzler RF, Detwiler PW, Riina HA et al (2002) Modified classification of spinal cord vascular lesions. J Neurosurg 96:145–156 (PMID: 12450276)
[2] Krings T, Geibprasert S (2009) Spinal Dural Arteriovenous Fistulas. American Journal of Neuroradiology 30 (4) 639-648
[3] Geibprasert S, Pereira V, Krings T et al (2008) Dural arteriovenous shunts: A new classification of craniospinal epidural venous anatomical bases and clinical correlations. Stroke 39: 2783–2794
[4] Jeng Y, Chen DYT, Hsu HL et al (2015) Spinal Dural Arteriovenous Fistula: Imaging Features and Its Mimics. Korean J Radiol Sep-Oct; 16(5): 1119–1131 (PMID: 26357504)
[5] Rangel-Castilla L, Holman P.J, Krishna C et al (2011) Spinal extradural arteriovenous fistulas: a clinical and radiological description of different types and their novel treatment with Onyx. Journal of Neurosurgery: Spine 15:541-549
[6] Kim LJ, Spetzler RF (2006) Classification and surgical management of spinal arteriovenous lesions: arteriovenous fistulae and arteriovenous malformations. Neurosurgery Nov;59(5 Suppl 3):S195-201 (PMID: 17053603)
URL: | https://eurorad.org/case/15181 |
DOI: | 10.1594/EURORAD/CASE.15181 |
ISSN: | 1563-4086 |
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