Ultrasound
Uroradiology & genital male imaging
Case TypeAnatomy and Functional Imaging
Authors
Athina C. Tsili, Christina Naka, Vasilios Maliakas, Maria I. Argyropoulou
Patient32 years, male
A 32-year-old male patient presented with a non-palpable right intratesticular mass, incidentally detected on ultrasound examination, due to subfertility. Laboratory analysis, including tumour markers, was unremarkable. MRI examination of the scrotum followed.
Sonography of the scrotum revealed the presence of a small right intratesticular mass lesion, measuring 7 mm in maximal diameter (Fig 1). The mass had well-defined margins and mainly low echogenicity, when compared to normal testicular parenchyma. Power Doppler examination showed rich lesion vascularity (Fig 1b).
MRI of the scrotum showed right testicular lesion involving the interlobar region, mainly hypointense and isointense on T2WI and T1WI, respectively (Fig 3). No areas of restricted diffusion were revealed within the mass. An early, strong contrast-enhanced followed by gradual de-enhancement (type III curve) was detected on dynamic contrast-enhanced imaging (Fig 4). Right tunica albuginea was intact. The right paratesticular space and the ipsilateral spermatic cord were normal.
The histologic diagnosis of a benign Leydig cell tumour was made, following right orchiectomy.
Background
Leydig cell tumours (LCTs) are included in the category of sex cord-gonadal stromal tumours of the testis. They constitute approximately 4-6% of adult testicular neoplasms and 10-30% of testicular tumours in infants and children. These tumours are usually benign, malignant behavior occurs in about 10% of cases [1-4].
The widespread use of US has resulted in an increase of incidentally discovered non-palpable small solid testicular lesions, which up to 80 % of cases are benign, with LCTs being the most frequent [5, 6]. Testis-sparing surgery is recommended in small LCTs, provided that pathology fails to reveal aggressive features [7].
Imaging perspective
Characterisation of testicular mass lesions is initially made upon US examination. However, the sonographic appearance of LCTs is variable and often non-specific. Peripheral hypervascularity in a small, hypoechoic testicular mass, with little or no internal colour Doppler flow may suggest the possibility of a LCT [1, 8]. LCT may be suggested by the findings of a short filling time or by a circumferential vessel with a rapid centripetal filling on contrast-enhanced US, combined with a "harder" appearance in real-time tissue elastography, in cases of a small and peripherally located hypoechoic tumour [9, 10].
At conventional MRI, LCTs have been described as isointense on T1WI and hypointense on T2WI, with marked homogeneous enhancement. In addition, they may also demonstrate capsular high T2 signal and a high-signal-intensity central scar on T2WI. However, MRI findings are not sufficiently specific to allow confident exclusion of alternative diagnoses, especially testicular germ cell tumours [1, 3, 4, 11]. Data regarding DWI characteristics of LCTs are lacking.
Mangarano et al. reported an overall diagnostic accuracy of 93% for MRI in differentiating LCTs from testicular seminomas. The presence of a well-defined testicular mass, with markedly hypointense T2 signal, homogeneous contrast enhancement, rapid and marked wash-in, followed by a prolonged wash-out was considered as suggestive of the diagnosis of LCTs. On the contrary, seminomas had blurred margins, weak hypointense T2 signal, weak T1 hyperintensity and weak and progressive wash-in, with an absent wash-out [12]. Sanharawi et al. in a study evaluating the qualitative, semi-quantitative and quantitative parameters of non-palpable testicular tumours, incidentally found on US by dynamic contrast-enhanced MRI reported higher peak, shorter time to peak, higher initial enhancement slope, higher Ktrans and Kep for LCTs compared to seminomas [13].
[1] Woodward PJ, Sohaey R, O’Donoghue MJ, Green DE (2002) From the Archives of the AFIP. Tumors and Tumorlike Lesions of the Testis: Radiologic-Pathologic Correlation. RadioGraphics 22:189-216 (PMID: 11796908)
[2] Dogra VS, Gottlieb RH, Oka M, Rubens DJ (2003) Sonography of the Scrotum. Radiology 227:18-36 (PMID: 12616012)
[3] Cassidy FH, Ishioka KM, McMahon CJ (2010) MR imaging of scrotal tumors and pseudotumors. Radiographics 30:665-83 (PMID: 20462987)
[4] Fernández GC, Tardáguila F, Rivas C, et al (2004) Case report: MRI in the diagnosis of testicular Leydig cell tumour. Br J Radiol 77:521-4 (PMID: 15151977)
[5] Rocher L, Ramchandani P, Belfield J, et al (2016) Incidentally detected non-palpable testicular tumours in adults at scrotal ultrasound: impact of radiological findings on management Radiologic review and recommendations of the ESUR scrotal imaging subcommittee. Eur Radiol 26:2268-78 (PMID: 26497666)
[6] Leonhartsberger N, Ramoner R, Aigner F, et al (2011) Increased incidence of Leydig cell tumours of the testis in the era of improved imaging techniques. BJU Int 108:1603-7 (PMID: 21631694)
[7] Albers P, Albrecht W, Algaba F, et al. (2015) Guidelines on testicular cancer. European Association of Urology Testicular-Cancer_LR.pdf (PMID: 26297604)
[8] Maizlin ZV, Belenky A, Kunichezky M, Sandbank J, Strauss S (2004) Leydig cell tumors of the testis: gray scale and color Doppler sonographic appearance. J Ultrasound Med 23:959-64 (PMID: 15292565)
[9] Cantisani V, Olive M, Di Segni M, et al (2012) Contrast-enhanced ultrasonographic (CEUS) and elastosonographic features of a case of testicular Leydig tumor. Ultraschall Med 33:407-9 (PMID: 22623134)
[10] Lock G, Schröder C, Schmidt C, Anheuser P, Loening T, Dieckmann KP (2014) Contrast-Enhanced Ultrasound and Real-Time Elastography for the Diagnosis of Benign Leydig Cell Tumors of the Testis-A Single Center Report on 13 Cases. Ultraschall Med 35:534-9 (PMID: 25140496)
[11] Tsitouridis I, Maskalidis C, Panagiotidou D, Kariki EP (2014) Eleven patients with testicular Leydig cell tumors: clinical, imaging, and pathologic correlation. J Ultrasound Med 33:1855-64 (PMID: 25253834)
[12] Manganaro L, Vinci V, Pozza C, et al (2015) A prospective study on contrast-enhanced magnetic resonance imaging of testicular lesions: distinctive features of Leydig cell tumours. Eur Radiol 25:3586-95 (PMID: 25981218)
[13] Sanharawi JE, Correas JM, Glas L, et al (2016) Non-palpble incidentally found testicular tumors: Differentiation between benign, malignant and burned-out tumors using dynamic contrast-enhanced MRI. Eur J Radiol 85: 2072-2082 (PMID: 27776661)
URL: | https://eurorad.org/case/15233 |
DOI: | 10.1594/EURORAD/CASE.15233 |
ISSN: | 1563-4086 |
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.