EURORAD ESR

Case 16011

Pulmonary Langerhans cell histiocytosis in an end-stage.

Author(s)
MªLuisa Collado Torres, Isabel Rivera Campos, Victoria Cuartero Revilla, Paula Mª Hernández Guilabert, David J. Petite Felipe, Clara Salas Antón

Manuela Falla 1 Majadahonda, Spain; Email:marisact90@hotmail.com
 
Patient
female, 61 year(s)
 
 
  • Figure 1
    Chest X-ray

    Bilateral interstitial alteration without loss of volume. Increased caliber of pulmonary arteries (yelow arrows)

     
    Area of Interest: Respiratory system; Imaging Technique: Conventional radiography; Procedure: Computer Applications-Detection, diagnosis; Special Focus: Cysts;
     
     
  • Figure 2
    Unenhanced coronal chest CT

    Diffuse, symmetric parenchymal involvement, with cystic changes in lower lung lobes and fibrosis in upper lung lobes.

     
    Area of Interest: Respiratory system; Imaging Technique: CT-High Resolution; Procedure: Computer Applications-Detection, diagnosis; Special Focus: Cysts;
     
     
  • Figure 3
    Unenhanced axial chest CT (upper lung lobes)

    Shows cysts (most of 5mm) and peribronchial fibrotic changes

     
    Area of Interest: Respiratory system; Imaging Technique: CT-High Resolution; Procedure: Computer Applications-Detection, diagnosis; Special Focus: Cysts;
     
     
  • Figure 4
    Unenhanced axial chest CT (lower lung lobes)

    Notice the irregular cysts, with a size less than one centimeter and confluent.

     
    Area of Interest: Respiratory system; Imaging Technique: CT-High Resolution; Procedure: Computer Applications-Detection, diagnosis; Special Focus: Cysts;
     
     
  • Figure 5
    pathological anatomy
     

    Granuloma constituted by Langerhans cells. These cells have a slightly eosinophilic clear cytoplasm and a nucleus with a central cleft. (HE stain).

     
    Area of Interest: Respiratory system; Imaging Technique: Percutaneous; Procedure: Biopsy; Special Focus: Pathology;

    Immunohistochemical staining for CD1a is positive, characteristics of the PLCH

     
    Area of Interest: Respiratory system; Imaging Technique: Percutaneous; Procedure: Biopsy; Special Focus: Pathology;
     
     
Bilateral interstitial alteration without loss of volume. Increased caliber of pulmonary arteries (yelow arrows)
 
Diffuse, symmetric parenchymal involvement, with cystic changes in lower lung lobes and fibrosis in upper lung lobes.
 
Shows cysts (most of 5mm) and peribronchial fibrotic changes
 
Notice the irregular cysts, with a size less than one centimeter and confluent.
 
Granuloma constituted by Langerhans cells. These cells have a slightly eosinophilic clear cytoplasm and a nucleus with a central cleft. (HE stain).
 
Immunohistochemical staining for CD1a is positive, characteristics of the PLCH
 
 
 
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