EURORAD ESR

Case 71

Nasopharyngeal carcinoma of the Regaud type

Author(s)
Lemort M, Leurquin M
 
Patient
male, 32 year(s)

Clinical History

Large tumour of the nasopharynx found after complaints of persistant facial pain

Imaging Findings

This patient, a woodworker, was referred in our institution for staging of a large rhinopharyngeal tumour discovered after persistent pain following extraction of a right superior molar tooth. A trigeminal neuralgy was already diagnosed. A MR examination is performed using following sequences : T1w SE axial and frontal pre and post Gd DOTA, T2w SE axial. Where is the posterior limit of the lesion ? What about the masticator space ? Is there any intracranial extension ? How do you explain the high signal on the T2w images of the mastoid cells ?

Discussion

Both the retropharyngeal spaces and the left prevertebral space are involved. The tumour infiltrates the masticator space with a perineural extension around the V3 nerve up to Meckel's cave. The intracranial extension follows a perineural way (V3 --> foramen ovale --> Meckel's cave) and a contiguous way through the sphenoid sinus. The hypersignal in the mastoid cells is caused by middle-ear fluid resulting from Eustachian tube malfunction (probably due to a tumour infiltration of the torus tubarii). Diagnosis was confirmed by biopsy : nasopharyngeal epithelioma (Regaud type). This refers to an undifferenciated nasopharyngeal carcinoma with foci of cells from epithelial origin (ref.1-3). The patient was only partially treated by chemo- and radiotherapy because he was lost of follow-up.

Final Diagnosis

Undifferenciated nasopharyngeal carcinoma (Regaud type)
 

References

Citation

Lemort M, Leurquin M (2000, Jan 17).
Nasopharyngeal carcinoma of the Regaud type, {Online}.
URL: http://www.eurorad.org/case.php?id=71
 
  • Figure 1
    Axial T1W SE before and after contrast
    a b c d  

    Pre-contrast, see 1c for description

    Pre-contrast, see 1d for description

    Note the huge enhancing mass involving the central skull base, the masticator space, the prevertebral space, the pterygo-palatine fossa

    Note the involvement of the Meckel's cave on the left side

     
  • Figure 2
    Post-contrast (Gd IV) coronal sections, T1W SE
    a b c d  

    Note the filling of the nasal fossa and the retention changes in the left maxillary sinus

    Note the disruption of the posterior inner wall of the left maxillary antrum, as the deep posterior extension

    There was a disruption of the skull base around the left foramen ovale, involvement of the cavernous sinus and encasement of the left internal carotid artery

    Same comments as 1c

     
Figure 1

Axial T1W SE before and after contrast

Figure 1a
Pre-contrast, see 1c for description
 
Figure 1b
Pre-contrast, see 1d for description
 
Figure 1c
Note the huge enhancing mass involving the central skull base, the masticator space, the prevertebral space, the pterygo-palatine fossa
 
Figure 1d
Note the involvement of the Meckel's cave on the left side
 
Figure 2

Post-contrast (Gd IV) coronal sections, T1W SE

Figure 2a
Note the filling of the nasal fossa and the retention changes in the left maxillary sinus
 
Figure 2b
Note the disruption of the posterior inner wall of the left maxillary antrum, as the deep posterior extension
 
Figure 2c
There was a disruption of the skull base around the left foramen ovale, involvement of the cavernous sinus and encasement of the left internal carotid artery
 
Figure 2d
Same comments as 1c
 
 
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