Case 77
Midgut carcinoid tumor
Author(s)
AS Rangheard, C Dromain, A Loshkajian, R Sigal
Patient
female, 45 year(s)
Clinical History
flushes, diarrhea, palpitations and abdominal pain.
Imaging Findings
A 45-year old woman was admitted to the hospital with a
4 months history of flushing associated to diarrhea,
palpitations and abdominal pain. The abdominal examination
showed a nodular hepatomegaly. Biologically was found an
urinary 5-HIAA excretion (normal ranged from 10 to 80 umol/24 h).
An ultra-sonography and an abdominal computed tomography
(CT) were performed.
CT exploration : After administration of an oral contrast
medium, a dual-phase helical CT was performed : before and
after injection of a iodine contrast medium (100 ml).
Discussion
Carcinoid tumors arise from the bowel distal to the ligament
of Treitz(1).Their typical manifestion is the carcinoid
syndrome with flush,diarrhea and palpitations(3),associated
to an urinary 5- HIAA excretion(2). Carcinoid tumors tend
to metastasize to liver, bone and lung (1). Hepatic metastases
are hypervascular: isodense relative to the liver, and become
hyperdense after injection of a iodine contrast medium (1).
The primary tumor is not always identified on CT examination
because of its relatively small size(4).When it is seen, it
appears as a soft tissue mass involving the bowel, or a focal
bowel wall thickening. CT frequently reveals secondary mesentery
changes as masses associated with radiating soft tissue strandS (1;4).
Final Diagnosis
midgut carcinoid tumor
MeSH
-
Carcinoid Tumor
[C04.557.470.200.025.200]
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
References
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[1]
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[2]
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[3]
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[4]
Citation
AS Rangheard, C Dromain, A Loshkajian, R Sigal (2000, Apr 3).
Midgut carcinoid tumor, {Online}.
URL: http://www.eurorad.org/case.php?id=77