Chronic recurrent multifocal osteomyelitis (CRMO) is an idiopathic inflammatory skeletal disorder of children and young adults that is characterized by multifocal non pyogenic inflammatory bone lesions [1].
The cause remains unknown though recently a genetic component has been suggested. Its association with skin lesions or inflammatory bowel disease is well documented [1, 2]. There is also a close link with SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis). By some authors, SAPHO is regarded as the adult form of CRMO and vice versa [2].
The onset of clinical symtomps is often insidious and non specific with exacerbations and remissions. Systemic manifestations such as fever, weight loss and lethargy may be present but are unusual. Laboratory tests may be normal, and pain is typically localised, even in a multifocal disease [1].
Most cases (up 85%) occur in children (average age of 10 years) with female predominance. Lesions typically involve the methaphyses of tubular bones with predilection for the lower extremities, followed by the clavicle, spine, ribs, mandible and pelvis [1, 3].
Symmetric involvement is common and multifocality is virtually always present [3, 4].
Radiological and histopathological findings of CRMO are similar to chronic infectious osteomyelitis which initially appears on radiography as lytic destruction within the methaphysic area adjacent to the physis, demarcated by a thin sclerotic rim. These inflammatory changes may progress to involve the diaphysis with periosteal new
bone formation [3-5]. During new exacerbations, small lytic lesions and periosteal new bone formations appear as signs of activity. In the reparative disease phase, areas of metaphyseal and epiphyseal destruction healing with sclerosis are present [3, 5].
MRI is highly sensitive to diagnose hidden lesions and extremely accurate to evaluate disease activity and local extent, and helpful for biopsy guidance and evaluation of long-standing disease. Active disease appears as areas of high signal on T2WI or STIR images, and decreased signal intensity on T1-WI. Quiescent disease correlates with low signal on T1 and T2 WI images, corresponding to sclerosis, possibly with scattered areas of high signal related to fatty marrow.
Histophatology is that of non specific inflammation, with fibrosis and/or hyperostotic regeneration [5, 6].
CRMO is a diagnosis of exclusión and differention diagnosis mainly includes infectious osteomyelitis and tumour or tumour-like lesions. Biopsy is needed to exclude malignant disease [1, 2, 4-6].
CRMO is generally a self-limiting disease, however up to the 50% of patients may experience skeletal growth disturbances or deformities later in life [4, 5]. Radiologists should be familiar with the typical imaging findings of CRMO to prevent unnecessary multiple biopsies and long-term antibiotic treatment [1, 4-7].